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Validated in vitro and in vivo disease and safety models for drug screening

T-Maze Validation data

The T-maze continuous alternation task (T-CAT) is one of the methods implemented to evaluate the spatial exploratory performance in mice.

SCOPOLAMINE

MK-801

AGED MICE

SCOPOLAMINE

Scopolamine / Dose response (0.89, 1.78, 3.56 mg/kg)

Scopolamine / Donepezil acute (0.003, 0.01, 0.03, 0.1, 1 mg/kg)

Scopolamine / Donepezil chronic (0.003, 0.01, 0.03, 0.1, 1 mg/kg)

Scopolamine / Galantamine p.o. (0.3, 1, 5 mg/kg)

Scopolamine / Galantamine intranasal (0.03, 0.01, 0.3, 1, 2 mg/kg)

Scopolamine / Methylphenidate (0.1, 0.3, 1, 3 mg/kg acute-chronic)

Scopolamine / Caffeine (0.1, 0.3, 1, 3 mg/kg)

Scopolamine / Atomoxine (0.3, 1.78, 1, 3, 10 mg/kg acute-chronic)

Scopolamine / Amphetamine acute (0.01, 0.1, 0.3, 1 mg/kg)

Scopolamine / Amphetamine chronic (0.01, 0.1, 0.3, 1 mg/kg)

Scopolamine / Xanomeline (0.1, 0.3, 1, 3 mg/kg)

Scopolamine / Dextromethorphan+Bupropion (1, 3, 10 mg/kg)

Scopolamine / Kava (30, 50, 100, 150 mg/kg)

Scopolamine / Roflumilast (0.03, 0.3, 0.1 mg/kg)

Scopolamine / Gingko (50, 100, 150 mg/kg)

Scopolamine / Sildenafil (0.1, 0.3, 1, 3 mg/kg)

Scopolamine / Ketamine-Rapastinel (0.1, 3 mg/kg)

Scopolamine / ABT089 - ABT418 (10 to 1000 µg/kg)

Scopolamine / Varenicline (0.1, 0.3, 1, 3 mg/kg)

Scopolamine / NS-9283 - LY2087101 (0.1, 0.3, 1, 10 mg/kg)

LPS

LPS / Timepoint (250, 500 µg/kg - Days 7, 14, 21 post-LPS)

LPS / Cinnamaldehyde (10, 30, 100 mg/kg)

LPS / DHA (5, 10, 20 mg/kg)

LPS / Donepezil-Ibuprofen (0.3-50 mg/kg)

LPS / GRN-529 (0.1, 1, 3 mg/kg)

LPS / Ibuprofen day 7 (100 mg/kg)

LPS / Ibuprofen day 14 (100 mg/kg)

LPS / Indomethacin (3 mg/kg)

LPS / Memantine (0.3, 1, 3 mg/kg)

LPS / Methylene blue (10, 20, 50 mg/kg)

LPS / N-acetylcysteine (50, 100, 200 mg/kg)

LPS / Nilotinib (10, 20 mg/kg)

LPS / Resveratrol (3, 10, 30 mg/kg)

LPS / Spermidine (0.1, 0.3, 1, 3 mg/kg)

LPS / Sulindac (1, 3, 10 mg/kg)

LPS / VX-745 (0.5, 1.5, 4.5 mg/kg)

PCP

PCP / ASP2535 (0.1, 0.3, 1, 3 mg/kg)

PCP / Clozapine (0.0001, 0.0003, 0.001, 0.01, 0.1 mg/kg)

PCP / Donepezil (0.3, 1 mg/kg)

PCP / D-serine (30, 100, 150, 600 mg/kg)

PCP / N-Acetylcysteine (50, 100, 200 mg/kg)

PCP / Priopidine (1, 3, 10 mg/kg)

PCP / Risperidone (0.01 mg/kg)

PCP / Spermidine (0.3, 1, 10 mg/kg)

PCP / Nicotine (0.4 mg/kg)

PCP / vortioxetine-Modafinil (1, 3, 10 / 3, 10, 30 mg/kg)

MK-801

MK-801 / ASP2535 (0.1, 0.3, 1, 3 mg/kg)

MK-801 / Clozapine (0.001, 0.003, 0.01, 0.1 mg/kg)

MK-801 / Nicotine (0.4 mg/kg)

MK-801 / D-serine (30, 100, 150, 600 mg/kg)

MK-801 / Xanomeline (0.03, 0.1, 0.3, 1 mg/kg)

Aged mice

Aged mice Timepoint (2, 6, 12, 20 months old)

Aged mice / Donepezil (0.003, 0.01, 0.03, 0.1, 1 mg/kg)

Aged mice / Nicotine (0.4 mg/kg)

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