PERIPHERAL NEUROPATHIES

  • Peripheral neuropathy is the result of damages of the peripheral nervous system. These disorders can be caused either by a trauma or diseases as for example diabetes.
    NEUROFIT proposes animal and cellular models useful for the evaluation of the neuroprotective activity of your coumpounds.


    CISPLATIN : model of chemotherapy induced neuropathy

    Cisplatin is widely used as an antimitotic drug for treating various cancers. However, its employment is often limited by their neurotoxicity, including peripheral neuropathy.
    Neurofit developed this model to assess the neuroprotective properties of compounds aiming to counteract chemotherapy side effects.

  • CISPLATIN: Sensory neurons and Schwann cells co-culture


    • Survival
      Cisplatin induces cell death in a dose dependant manner.
      At each dose tested, NGF at 5 ng/ml is able to protect neurons against ciplatin damage.
    • Phosphatase acid
      Cisplatin induces cell death in embryonic sensory neurons and Schwann cells co-culture. NGF at 5 ng/ml is able to protect neurons against the cisplatin damage.

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  • Basal condition

    Sensory neurons and Schwann cells co-culture from rat embryos.
    Purified sensory neurons culture from rat embryos or from adult rat.

  • Taxol treatment

    Peripheral neuropathy is the result of damages of the peripheral nervous system induced by insult such as the neurotoxicity of taxol.

    Vincristine treatment

    Neurofit developed this model to assess the neuroprotective properties of compounds aiming to counteract chemotherapy side effects.