SCHIZOPHRENIA

  • Schizophrenia is a neurodegenerative disorder characterized by various symptoms such as disturbances in information processing and cognitive impairment. Among the characteristics of this disease, NEUROFIT proposes models inducing cognitive disturbances (poor working memory, concentration troubles…) and hyperactivity (agitation).


    MK-801

    Dizocilpine (MK-801) is a NMDA receptor antagonist often used to produce cognitive dysfunction.
    Neurofit proposes a cost-effective MK-801 based screening assay in the mouse T-maze alternation (single trial) that is responsive to memory / learning enhancer drugs such as nicotine or donepezil.

T-Maze (cognition)

  • Nicotine - Donepezil :

    Reversion of MK-801-induced cognitive deficit in the T-Maze alternation task in the mouse


  • Carbamazepine :

    Reversal effect of Carbamazepine on cognitive deficit induced by MK-801 in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.


  • Clozapine :

    Reversal effect of Clozapine on cognitive deficit induced by MK-801 in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-Maze.


  • Xanomeline :

    Reversal effect of Xanomeline on cognitive deficit induced by MK-801 in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

Open-Field (hyperactivity)

  • Total walked distance

  • Number of crossed squares

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