Tail Flick
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Presentation
- The tail flick test is a thermal hyperalgesia test in which the tail of the animal is subjected to a heat source. Once the animal feels uncomfortable, he removes spontaneously the tail (“tail flick”). Neurofit implements this test to evaluate the analgesic effect of your compounds.
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Compound testing
Pain killers are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.
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Endpoints
Latency (s) in the tail flick test
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Hot plate
The Hot plate test consists in a thermal pain measurement.
Paw pressure (Randall-Selitto test)
The paw pressure test consists in applying a uniformly increasing mechanical pressure on the animal paw.
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Acute Pain
Measure of the normal nociceptive thresholds upon application of painful stimuli remains the most used assay for the screening of analgesic potential of new drugs.