Hyperactivity in Open-Field

  • Presentation


    Psychotomimetic drugs, such as Phencyclidine (angel dust), produce schizophrenia-like symptoms in humans.
    In laboratory animals, they induce locomotor hyperactivity which is a widely used method for the screening of antipsychotic drug candidates.

  • Compound testing


    Antipsychotic drugs are usually tested in this model but other treatments could also be considered.

  • Endpoints


    Hyperactivity
    Total travelled distance
MK-801 INDUCED HYPERACTIVITY in Open Field

PHENCYCLIDINE INDUCED HYPERACTIVITY IN OPEN FIELD

SCHIZOPHRENIA: HYPERACTIVITY IN OPEN FIELD

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