Experimental Autoimmune Encephalomyelitis (EAE) in Lewis rat

  • Presentation


    EAE is a commonly used animal model which shares some degree of similarities with human multiple sclerosis (MS). EAE is induced by CNS antigens such myelin basic protein (MBP) which activates autoreactive T-cells responsible for CNS inflammation and demyelination. Within 10 days after the immunization with MBP of susceptible Lewis rats they develop a progressive weight loss and paralysis that can be assessed using semi-quantitative neurological scoring system.

  • Compound testing


    Effect of subchronic or chronic treatment of rats (typically starting before the appearance of first symptom) on:

    neurological score until complete recovery
    body weight

  • Endpoints


    Scoring
Dexamethasone model

    Dexamethsone treatment administrated from day 8 to 12 improves the clinical score of EAE rats.

    Body weight loss during the course of EAE.


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