ALZHEIMER'S DISEASE

  • Alzheimer’s disease is the most common age-related neurodegenerative disorder, characterized by the progressive degeneration of neuronal populations and the simultaneous loss of memory and cognitive functions.


    Amyloid-β model

    Amyloid-β i.c.v injection induces learning deficits and a dysfunction of the cholinergic system. This model mimics the cognitive deficit associated with Alzheimer’s disease and can be assessed at Neurofit using the passive avoidance test.

  • Compound testing


    Disease modifiers are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.

  • Endpoints


    ☐ Latency in the passive avoidance test.
  • Passive avoidance
  • Step through Latency.



    Amyloid-β rats :
    Improved learning/memory in Amyloid-β rats treated with Memantine.

    Acute and chronic Memantine revert the performance of Aβ rats to the level of Sham specimen.
  • Step through Latency.



    Amyloid-β rats :
    Improved learning/memory in Amyloid-β rats treated with Donepezil .

    Chronic Donepezil revert the performance of Aβ rats to the level of Sham specimen.

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