Rat model of Parkinson's disease - compound testing

Newsletter # 44



Animal models

Parkinson's disease (PD) is a neurodegenerative disorder with motor symptoms caused by the death of dopaminergic (DA) neurons in the striatum. There is no medication to cure or halt this disease yet.
6-hydroxydopamine (6-OHDA) is a neurotoxin widely used in lab animals to produce striatal dopamine depletion together with motor deficit.


  • Motor deficits in 6-OHDA rats

  • A : Beam walking

  • B : Forelimb-use asymmetry

  • C : Locomotor activity

  • Depletion of striatal dopamine in 6-OHDA rats

  • GROUPS

    Dopamine level (ng/g of striatum)
    Sham 6783 (+/-) 600
    Vehicle - treated 6-OHDA rats Below the limit of quantification

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

If you need further information, please do not hesitate to contact us, we will reply within few days. Custom protocol

On a regular basis we distribute newsletters with scientific information on our research services. If you wish to receive these, please :