PERIPHERAL NEUROPATHIES
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Peripheral neuropathy is the result of damages of the peripheral nervous system. These troubles can be caused either by a trauma or diseases as for example diabetes.
NEUROFIT proposes animal and cellular models able to evaluate the neuroprotective activity of your coumpounds.
TAXOL : model of chemotherapy induced neuropathy
Taxol is widely used as an antimitotic drug for treating various cancers. However, its employment is often limited by their neurotoxicity.
Neurofit developed this model to assess the neuroprotective properties of compounds aiming to counteract chemotherapy side effects.
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Compound testing
Neuroprotectant are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.
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Endpoints
☐ Neuronal survival dose response curve (MTT activity)
☐ Neuronal death dose response curve (LDH activity)
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Purified cultures of sensory neurons:
Taxol induced sensory neurons death.
NGF is able to protect sensory neurons against this injury. -
Co-cultures of sensory neurons and Schwann cells :
Taxol induces sensory neuron cell death.
NGF is able to protect sensory neurons against this injury.
TAXOL intoxication
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Viability and survival test
Purified cultures of sensory neurons or co-cultures from sensory neurons and Schwann cells are injured by chemotherapeutic drugs.
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