PERIPHERAL NEUROPATHIES
-
Peripheral neuropathy is the result of damages of the peripheral nervous system. These troubles can be caused either by a trauma or diseases as for example diabetes.
NEUROFIT proposes animal and cellular models able to evaluate the neuroprotective activity of your coumpounds.
CISPLATIN : model of chemotherapy induced neuropathy
Cisplatin is widely used as an antimitotic drug for treating various cancers. However, its employment is often limited by their neurotoxicity.
Neurofit developed this model to assess the neuroprotective properties of compounds aiming to counteract chemotherapy side effects.
-
Compound testing
Neuroprotectant are usually tested in this model but other treatments could also be considered. Please feel free to contact us to discuss the feasibility of your study.
-
Endpoints
☐ Neuronal survival dose response curve (MTT activity)
☐ Neuronal death dose response curve (LDH activity)
-
-
Purified cultures of sensory neurons :
Cisplatin induced cell death in sensory neurons.
At each dose of cisplatin, NGF at 5 ng/ml is able to protect neurons against the ciplatin damage. -
Co-cultures of sensory neurons and Schwann cells :
Cisplatin induces cell death in a dose dependant manner.
At each dose tested, NGF at 5 ng/ml is able to protect neurons against ciplatin damage.
CISPLATIN intoxication
You could also be interested in
-
Viability and survival test
Purified cultures of sensory neurons or co-cultures from sensory neurons and Schwann cells are injured by chemotherapeutic drugs.
-
Vincristine
Model of chemotherapy induced neuropathy, the result of damages of the peripheral nervous system.
Taxol
Model of chemotherapy induced neuropathy, the result of damages of the peripheral nervous system.