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Newsletter # 116
In vivo studies
Methotrexate is a widely recognized therapeutic agent, known for its powerful immunosuppressive and anti-inflammatory properties. It has proven essential in the treatment of various autoimmune diseases, inflammatory conditions, cancers, and even certain gynecological disorders.
As a first-line disease-modifying antirheumatic drug Methotrexate plays a pivotal role in managing autoimmune and inflammatory diseases. It is also the go-to systemic therapy for moderate-to-severe psoriasis when topical treatments or phototherapy fail to provide adequate relief.
As a first-line disease-modifying antirheumatic drug Methotrexate plays a pivotal role in managing autoimmune and inflammatory diseases. It is also the go-to systemic therapy for moderate-to-severe psoriasis when topical treatments or phototherapy fail to provide adequate relief.
Exciting preclinical data from Neurofit further reinforces Methotrexate's therapeutic potential.
In an established model of allergic contact dermatitis, the systemic administration of Methotrexate effectively alleviated ear swelling induced by oxazolone – a well-known hapten that easily penetrates the epidermis to provoke localized immune response. These results not only support Methotrexate's anti-inflammatory mechanisms but also align with its clinical use in treating a wide range of inflammation-driven conditions.
In an established model of allergic contact dermatitis, the systemic administration of Methotrexate effectively alleviated ear swelling induced by oxazolone – a well-known hapten that easily penetrates the epidermis to provoke localized immune response. These results not only support Methotrexate's anti-inflammatory mechanisms but also align with its clinical use in treating a wide range of inflammation-driven conditions.
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The rat model of oxazolone-induced ear swelling is a reliable way to study skin inflammation, which mimics allergic reactions in humans. When the ear is exposed to oxazolone, it becomes inflamed and swells (red column). Treatment with Methotrexate reduces this swelling in a dose-dependent manner, as shown by the three respective blue columns representing increasing doses.
The effects of other anti-psoriatic and anti-dermatitis medications on oxazolone-induced ear swelling are available here
*, p ≤ 0.01 and ***, p ≤ 0.005 :
significantly different as compared to the oxazolone group
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