At Neurofit, we utilize the mouse marble burying paradigm as an in vivo model for OCD, mimicking compulsive-like behaviors. Indeed, we found that both Fluoxetine and Memantine markedly reduce the frenetic repetitive and stereotypic burying behaviors of mice. Additionally, their combination lacks any antagonistic effect. These findings reinforce the possibility of combining these treatments for a synergistic or complementary effect in managing compulsive behaviors without reducing the efficacy of either drug.