Evaluation of anti-depressant and/or anxiolytic drugs:
Venlafaxine validation

Newsletter # 66

Animal models


Venlafaxine (e.g. Effexor, Lanvexin, Viepax or Trevilor) is a psychoactive drug used for the treatment of depression or anxiety disorders. It is an antidepressant of the serotonin-norepinephrine reuptake inhibitor (SNRI) class.



Here we provide a clear-cut result that validates the effect of Venlafaxine in a behavioral test routinely used at NEUROFIT to test predictive value for anti-depressant and/or anxiolytic drugs.

  • Venlafaxine reverses natural compulsive behaviors
    of rodents placed in a novel environments




  • ■ Treatment with Venlafaxine reverses the burying behavior of mice placed in a novel environment.

    ■ Marble burying test is a known and validated paradigm to test the anti-depressant/anxiolytic effect of drug treatments in mouse.

    ■ Indeed, this test model has proved to be sensitive to the anxiolytics such as benzodiazepines, and to anti-depressants such as Fluoxetine (SSRI).


NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

If you need further information, please do not hesitate to contact us, we will reply within few days. Custom protocol

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