Translational model of DELAYED-TYPE HYPERSENSITIVITY

Newsletter # 60

Animal models


Delayed-Type Hypersensitivity (DTH) is an important in vivo manifestation of cell-mediated immunity. The development of DTH elicited by prior exposure to antigens involves T lymphocyte function. The DTH response provides thus an in-vivo window of T-cell response and serves as a convenient model to determine the efficacy of immunomodulators or immunosuppressants.

The rat model highlighted herein is translatable to the Delayed-Type Hypersensitivity reaction in human characterized by erythema and oedema at the site of antigen injection.



  • ■ Ear swelling as measured by an increased pinna thickness is a robust read-out to quantify the DTH reaction in rat.

    ■ Immunosuppressants such as dexamethasone or cyclophosphamide suppress this immune response.


NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

If you need further information, please do not hesitate to contact us, we will reply within few days. Custom protocol

On a regular basis we distribute newsletters with scientific information on our research services. If you wish to receive these, please :