Preclinical models for the evaluation of cognitive-enhancing drugs

Newsletter # 47



Animal models

Procognitive drugs are heterogeneous group of compounds with different mechanisms of action aiming to improve the cognitive deficit (including memory, attention, executive function, perception - associated with different psychiatric or neurological disorders such as Alzheimer's and Parkinson's diseases, Attention Deficit, Hyperactivity Disorder, schizophrenia ...).


NEUROFIT has 20 years of experience in running preclinical studies with procognitive drugs in experimental models of cognitive / memory deficit in mice or rats including the T-maze Continuous Alternation Task, Passive Avoidance Task, and Novel Object Recognition Test. We have generated high quality in-vivo data for a broad range of reference compounds using various pharmacological interventions, or time, to induce cognitive deficits associated with specific disease states.

  • Click on the drug name to see an example of its procognitive effect :

  • Amphetamine

    Reversal effect of Amphetamine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • Atomoxetine

    Reversal effect of Atomoxetine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • Caffeine

    Reversal effect of Caffeine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • Carbamazepine

    Reversal effect of Carbamazepine on cognitive deficit induced by MK-801 in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • CCMI

    Reversal effect of CCMI on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • Clozapine

    Reversal effect of Clozapine on cognitive deficit induced by MK-801 in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze..

  • Donepezil

    Reversal effect of Donepezil on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • Donepezil

    Passive avoidance

    Reversal effect of Donepezil on memory deficit induced by scopolamine in the rat. Memory was assessed by the ability of rats to avoid a punishing or aversive stimuli during the passive avoidance test.

  • Galantamine

    Reversal effect of Galantamine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • Memantine

    Reversal effect of Memantine on cognitive deficit induced by MLA in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • Methylphenidate

    Reversal effect of Methylphenidate on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • PNU 120596

    Reversal effect of PNU120596 on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • Nicotine

    Reversal effect of Nicotine on cognitive deficit induced by scopolamine in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.

  • Nicotine

    Passive avoidance

    Reversal effect of Nicotine on memory deficit induced by scopolamine in the rat. Memory was assessed by the ability of rats to avoid a punishing or aversive stimuli during the passive avoidance test.

  • Xanomeline

    Reversal effect of Xanomeline on cognitive deficit induced by MK-801 in the mouse. Cognitive function was assessed by the ability of mice to perform spontaneous, continuous and sustained alternation in the T-maze.



  • At NEUROFIT, we are aware that time is of essence in the development of new drugs that's why we try to minimize the study timeline as much as possible.
    If you are interested in further information, please do not hesitate to contact us. We would be more than happy to discuss with you about your projects and the services we can propose following your needs.

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

If you need further information, please do not hesitate to contact us, we will reply within few days. Custom protocol

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