Animal model for Rheumatoid Arthritis: Pristane induced arthritis in rat - Newsletter - Preclinical Contract Research Organization (CRO) for CNS and PNS disorders

Animal model for Rheumatoid Arthritis: Pristane induced arthritis in rat

Newsletter # 31

Animal models

Pristane-induced arthritis (PIA) is a preclinical model of arthritis that exhibits features of human rheumatoid arthritis (RA) such as symmetry of inflammation, chronic and relapsing course of disease, infiltration of T cells, and erosive destruction of cartilagenous peripheral joints. It is largely implemented to evaluate the mechanisms of inflammatory joint disease and also to test the efficiency of new anti-arthritic therapy.

NEUROFIT offers rapid, robust and validated PIA model in Dark-Agouti rats.

Quantitative measure of paw swelling in arthritic rats.

Dexamethasone fully prevents the paw swelling symptom of arthritis in rats.
Semi-quantitative scoring of experimental arthritis severity.

Dexamethasone fully prevents the appearance of clinical symptoms of arthritis in rats.

Other immune-driven inflammatory models are also available at Neurofit:

Model for Rheumatoid arthritis: Collagen-induced arthritis

Models for Multiple sclerosis such as the Relapsing-Remitting EAE in the rat

Model for Delayed-type hypersensitivity (DTH): Ovalbumin-induced DTH

Models for Contact dermatitis: Oxazolone-induced contact dermatitis

Model for general inflammation: Carrageenan air pouch model

For a complete listing of tests and models, please refer to our website. If you need further information, please do not hesitate to contact us.
We look forward to hearing from you.

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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Newsletter # 31

Animal models

Quantitative measure of paw swelling in arthritic rats.

Semi-quantitative scoring of experimental arthritis severity.

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NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.