Rat model of Parkinson's disease - compound testing

Newsletter # 44



Animal models

Parkinson's disease (PD) is a neurodegenerative disorder with motor symptoms caused by the death of dopaminergic (DA) neurons in the striatum. There is no medication to cure or halt this disease yet.
6-hydroxydopamine (6-OHDA) is a neurotoxin widely used in lab animals to produce striatal dopamine depletion together with motor deficit.


  • Motor deficits in 6-OHDA rats

  • A : Beam walking

  • B : Forelimb-use asymmetry

  • C : Locomotor activity

  • Depletion of striatal dopamine in 6-OHDA rats

  • GROUPS

    Dopamine level (ng/g of striatum)
    Sham 6783 (+/-) 600
    Vehicle - treated 6-OHDA rats Below the limit of quantification

NEUROFIT offers a range of validated in vitro and in vivo screening tests for psychiatry and neurology.

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